Whole Genome Trait Association in SVS

July 15, 2020 | 12:00 PM EDT

Presented by Gabe Rudy, VP of Product & Engineering, Golden Helix

Golden Helix’s SNP & Variation Suite (SVS) has been used by researchers around the world to do trait analysis and association testing on large cohorts of samples in both humans and other species. As Next-Generation Sequencing of whole genomes becomes more affordable, large cohorts of Whole Genome Sequencing (WGS) samples are available to search for additional trait association signals that were not found in array-based testing. In fact, recent papers have shown that WGS analysis using advanced GREML (Genomic Relatedness Restricted Maximum Likelihood) techniques is able to outperform micro-array based GWAS methods in the analysis of complex traits and proportion of the trait heritability explained.

Our latest update release of SVS has expanded the exiting maximum likelihood and GRM methods to support these new techniques. We have also enhanced various other association testing and prediction methodologies. Join us for our upcoming webcast where we will showcase:

  • Newly supported analysis workflow for whole genome variants using LD binning and enhanced GBLUP analysis
  • Enhanced gender correction using REML
  • Additional capabilities for genomic prediction and phenotype prediction

We are continually improving our products based on our customer’s feedback. We are looking forward to highlighting the exciting new features and select enhancements we have made in this upcoming webcast.